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Pentobarbital Sodium, a generic medication also known by the brand name Nembutal, belongs to a class of medications known as barbiturates. Nonselective depressants of the central nervous system are barbiturates. Nembutal is frequently used to reduce nervous system and brain activity. While it appears to lose its effectiveness after two weeks, it is utilized as a short-term insomnia treatment.

Nembutal can also be used to induce unconsciousness during surgery and as an emergency treatment for seizures. It is most frequently used to treat acute episodes of meningitis, eclampsia, tetanus, and status epilepticus while treating seizures. Nembutal is also used to lower intracranial pressure in patients with Reye's syndrome, traumatic brain injury, and cerebral ischemia induction of coma.

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The substance has the potential to become habit-forming because it belongs to the barbiturate family. With continued usage, tolerance to the drug as well as physical and psychological dependence may develop. The medication is the only injectable type of pentobarbital that has been authorized for sale in the United States, and it is produced and marketed by the Danish pharmaceutical company Lundbeck. When pentobarbital dosages are high, respiratory arrest results in mortality. The medication has been used to put people to death in the US. Because of its reputation for dependability and quickness in producing deadly effects, it is also one of the most widely used medications in euthanasia and drug assisted suicide.

Nembutal dosage is based on the patient's age, weight, and health. Nembutal may interact with birth control pills, hormone replacement estrogens, steroids, griseofulvin, doxycycline, other seizure drugs, MAO inhibitors, and blood thinners. A pregnant or nursing woman should not use this medication. Nembutal should not be abruptly stopped after prolonged use because it has the potential to become habit-forming. If it is, withdrawal symptoms may be quite severe.